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<br>Prolonged residence of mice in spaceflight is a scientifically robust and ethically ratified model of [alpha surge male muscle builder](http://www.ssongactors.co.kr/SSONG/bbs/board.php?bo_table=free&wr_id=264715) atrophy caused by continued unloading. Under the Rodent Research Program of the National Aeronautics and Space Administration (NASA), we assayed the large-scale mRNA and metabolomic perturbations in the quadriceps of C57BL/6j [Alpha Surge Male supplement support](http://www.gbsa.kr/bbs/board.php?bo_table=free&wr_id=679522) mice that lived in spaceflight (FLT) or on the ground (control or CTR) for approximately 4 weeks. The wet weights of the quadriceps were significantly reduced in FLT mice. Next-generation sequencing and untargeted mass spectroscopic assays interrogated the gene-metabolite landscape of the quadriceps. A majority of top-ranked differentially suppressed genes in FLT encoded proteins from the myosin or troponin families, suggesting sarcomere alterations in space. Significantly enriched gene-metabolite networks were found linked to sarcomeric integrity, immune fitness, [Alpha Surge Male formula](https://45.76.249.136/index.php?title=User:OnaSchuster03) and oxidative stress response
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